Antimicrobial peptide MPX relieves Enterohemorrhagic Escherichia coli-induced Intestinal Inflammation by Improving the Diversity of Intestinal Flora
作者单位：Sumy National Agrarian University College of Animal Science and Veterinary MedicineHenan Institute of Science and Technology College of Veterinary MedicineJiLin University
会议名称：《中国微生物学会兽医微生物学专业委员会暨中国畜牧兽医学会生物制品学分会2021年学术论坛》
会议日期：2021年
学科分类：090601[农学-基础兽医学] 09[农学] 0906[农学-兽医学]
摘 要：Escherichia coli is a facultative anaerobic bacteria that mainly exists in the gastrointestinal tract of humans and *** can cause the destruction of the host intestinal barrier and intestinal microecological *** intestinal microbiota participates in a variety of physiological functions and is an important factor in the development of the intestinal immune system and driving *** peptides are the body’s first line of defense against the invasion of pathogenic microorganisms and an important part of the body’s defense *** have found that antimicrobial peptides can change the body’s microbial composition and maintain the intestinal microecological *** previous study have found that the antimicrobial peptide MPX could alleviate the intestinal inflammatory response caused by *** infection and improve the intestinal barrier *** study the effect of antimicrobial peptide MPX on intestinal inflammation and changes in intestinal flora induced by *** this study,the antimicrobial peptide MPX pre-treatment and the intestinal microbiota of *** infected mice were subjected to 16 s rDNA sequencing to detect changes in the intestinal microbiota from a new perspective.48 male and female BALB/c mice were divided into normal group,antimicrobial peptide MPX group,control group(*** infection group) and antimicrobial peptide MPX+*** infection *** peptide MPX and Escherichia coli were administered and infected by gavage,and successfully established a model of *** infection in the intestinal flora of *** was found that the antimicrobial peptide MPX effectively relieves weight loss and clinical symptoms caused by *** *** ELISA test found that the antimicrobial peptide MPX reduced serum MPO,IL-2,IL-6,and TNF-α levels caused by *** infection,and the effect of 14 days was better than 28 *** results of HE staining and scanning electron microscopy showed that *** infe