Infant colic treated with Bifidobacterium longum CECT7894 and Pediococcus pentosaceus CECT8330:a randomized,double-blind,placebo-controlled trial
作者单位：Department of NutritionChengdu Women's and Children's Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of China School of Exercise and Nutritional SciencesSan Diego State University Department of Child Health CareQingbaijiang Maternal and Child Health Hospital Department of Child Health CareChengdu Caojiaxiang Community Healthcare Center
会议名称：《第五届益生菌益生元科学大会》
会议日期：2023年
学科分类：1002[医学-临床医学] 08[工学] 100202[医学-儿科学] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 10[医学]
摘 要：Background:Colic is a common condition in infants 4 months of *** to treat infant colic with probiotics have shown variable efficiency and overall low evidence of *** this work,we tested the hypothesis that oral administration of Bifidobacterium longum and Pediococcus pentosaceus mix would improve the symptoms of infantile ***:A total of 112 exclusively or predominately breastfed infants aged 2 months and meeting the ROME IV criteria for infantile colic were *** infants were randomized in a double-blind,placebo-controlled trial to receive orally administered probiotics（intervention group,IG,n=48）,*** CECT7894（KABP042） and *** CECT8330（KABP041）(1×10～9 colony forming units),or placebo（placebo group,PG,n=42） daily for 21 *** reference product（placebo） is an identical pure sunflower oil without *** enrollment and research plan were reviewed and approved by the institutional ethics committee of Chengdu Women s and Children s Central Hospital and written informed consent was obtained from parents of each *** study included five visits to the clinics:i) a baseline visit,which corresponded to the day when parents were referred to the pediatrician with the main complaint of the baby s crying and/or fussing without a definite reason;ii) day 1 visit,required to verify ROME IV colic diagnostic criteria,where participants were randomized for intervention;and iii) day 7,14 and 21 visits,that corresponded to the weekly assessments during the 3-week intervention phase from day *** probiotics and the placebo products were similar in smell,taste,and *** products were only labelled with the randomization number,batch number,expiry date,and the statement ‘For clinical trial use only .The random allocation sequence was generated by an independent statistician,and nurses enrolled the participants,and pediatricians assigned participants to the intervention groups based on the *** and chi