Antimicrobial AApeptides
作者单位：Department of ChemistryUniversity of South Florida
会议名称：《ASTF2023（第五届）抗菌科学与技术论坛》
会议日期：2023年
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 10[医学]
摘 要：The identification and development of sequence-specific peptidomimetics is of significance in bioorganic chemistry and chemical biology.A new class of peptidomimetics termed AApeptides was recently developed by our *** proper design,AApeptides could exhibit broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria by mimicking the mechanism and action of host-defense *** addition,they could be designed to mimic HRl in Spike protein of SARS-CoV-2 and effectively prevent the virus fusion into host *** results imply AApeptides could be developed as new class of antimicrobial agents.