Metabolic disturbances in patients with narcolepsy
作者单位：Sichuan University
会议名称：《中国睡眠研究会第十五届全国学术年会》
会议日期：2023年
摘 要：Objectives: Narcolepsy is a chronic sleep-wake disorder driven by selective and irreversible orexin neuron *** with narcolepsy also present various metabolic alterations, proven to be with increased susceptibility than the control *** performed a systematic review and meta-analysis to delineate the prevalence rates of respective metabolic disturbances in ***: A meta-analysis was conducted on the prevalence rates of ‘any metabolic disturbances in patients with *** databases(i.e., PubMed, Web of Science, EBSCO, and Cochrane Library) were searched up to date on 07 September *** effect size(ES) of the prevalence rate was the pooled mean with the random *** age cut-off of 18 years was chosen for sensitive *** the ES with insufficient values to perform meta-analysis, a systematic review was ***: A total of 28 studies(n=15281) were included in this *** studies(n=2351) were on narcoleptic subjects under 18 years old, and the other 18 studies(n=12930) were on older ones(≥ 18y).We found four metabolic disturbances were primarily reported in narcolepsy and the meta-analysis showed the prevalence rates were 31.9%(95%CI: 27.7%-36.1%) in overweight and 27.1%(95%CI: 21.5%-32.7%) in obesity, 28.8%(95%CI: 9.5%-48.1%) in dysglycaemia, 28.7%(95%CI: 16.7%-40.7%) in dyslipidemia, and 43.9%(95%CI: 20.7%-67.2%) in hypertension, ***, the prevalence rate of metabolic syndrome was 36.1%(95%CI: 14.6%-57.6%), which was found to be more prevalent in narcolepsy type *** addition, precocious puberty was also crossly recounted in pediatric narcoleptic studies, with a prevalence rate being 6.9%(95%CI: 12.7%-21.0%).Whilst, Vitamin D(54.8%, 95%CI: 37.1%-72.5%) and Vitamin 12 deficiency were found in adult narcoleptic *** terms of the subgroup analysis of age, the prevalence rate of overweight was increased from underage(18y: 27.4%, 95%CI: 23.7%-31.1%) to adults(≥18y: 36.0%, 95%CI: