Association of insomnia, insulin resistance traits and cardiovascular diseases risk: A two-step Mendelian randomization study
作者单位：The Affiliated Brain Hospital of Guangzhou Medical University The First Affiliated Hospital of Xinxiang Medical University Guangdong Provincial People's Hospital Zhejiang University School of Medicine King's College London British Heart Foundation Centre of Research Excellence
会议名称：《中国睡眠研究会第十五届全国学术年会》
会议日期：2023年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：Aims: Insomnia increases the risk of cardiovascular diseases(CVDs), but whether IR or its related traits mediate the underlying associations is *** conducted a two-step two-sample Mendelian randomization(MR) study to address these *** and results: We selected genetic variants of insomnia, IR and its traits(i.e., FG, FI, HbA1c, TG, HDL-C, and T2DM) as instrumental variables, while summary-level data of five CVDs(i.e., HF, CAD, AF, MI and hypertension) were served as the main outcomes, which derived from previous genome-wide association studies(GWASs).In the MR analysis, genetically predicted insomnia symptom was significantly associated with five CVDs risks and six IR related traits after correcting for multiple tests, while genetically predicted IR and related traits, such as T2DM, TG and HDL-C were associated with four CVDs *** the mediation analysis, we found strong evidence for the mediating effects of IR, TG, HDL-C, and T2DM in the causal pathway from insomnia to four CVDs except for ***, the major contributors were IR(ranging from 15.3% to 50.3% mediation) and T2DM(ranging from 8.4% to 28.9% mediation) among those potential *** MR analysis provided further evidence supporting the potential mediation effects of IR and related traits in the causal pathway between insomnia and ***: These results suggest that genetically predicted insomnia is associated with higher risk of CVDs, with considerable mediation by IR and *** on these factors may have the potential of substantially reducing the burden of CVDs attributable to insomnia.