Effectiveness and mechanisms of adipose-derived stem cell therapy in animal models of Parkinson's disease:a systematic review and meta-analysis
作者单位：Key Laboratory of Human Disease Comparative MedicineChinese Ministry of HealthBeijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciencesand Comparative Medicine CenterPeking Union Medical College
会议名称：《第十六届中国实验动物科学年会》
会议日期：2023年
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学]
摘 要：Animal models provide an opportunity to assess the optimal treatment way and the underlying mechanisms of direct clinical application of adipose-derived stem cells(ADSCs).Previous studies have evaluated the effects of primitive and induced ADSCs in animal models of Parkinson’s disease(PD).Here,eight databases were systematically searched for studies on the effects and in vivo changes caused by ADSC *** assessment was conducted using a 10-item risk of bias *** thesubsequent meta-analysis,study characteristics were extracted and effect sizes were *** outof 2,324 published articles(n=169 animals)were selected for further *** ADSC therapy,the rotation behavior(10 experiments,n=156 animals) and rotarod performance(3 experiments,n=54 animals) were improved(P 0.00001 and P=0.0003,respectively).The rotation behavior test reflects the functional recovery,which may be due to the neurogenesis from neuronally differentiated ADSCs,resulting in a higher pooled effect size of standard mean difference(SMD)(-2.59;95%Cl,-3.57 to-1.61) when compared to that of primitive cells(-2.18;95% Cl,-3.29 to-1.07).Stratified analyses by different time intervals indicated that ADSC intervention exhibited a long-term *** the transplantation of ADSCs,tyrosine hydroxylase-positive neurons recovered in the lesion area with pooled SMD of 13.36[6.85,19.86].Transplantation of ADSCs is a therapeutic option that shows long-lasting effects in animal models of *** potential mechanisms of ADSCs involve neurogenesis and neuroprotective *** standardized induction of neural form of transplanted ADSCs can lead to a future application in clinical practice.