Single-cell transcriptome analysis reveals smad3/Src/Pou4f1 signaling as a key pathway for macrophage-myofibroblast transition in lung carcinoma
作者单位：Department of Anatomy and Histology and EmbryologySchool of MedicineTongji University
会议名称：《中国解剖学会2021年年会》
会议日期：2021年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Macrophage-myofibroblast transition (MMT) is a newly identified process to generate collagen-producing myofibroblasts locally in fibrosing tissues,but the underlying mechanisms are still largely unknown.Here,we uncover the underlying mechanism of MMT by analyzing bone marrow derived macrophage (BMDM) and MMT cells with RNA-sequencing at single-cell resolution.