Study on the molecular mechanism of Huang jing in the treatment of type 2 diabetes mellitus based on network pharmacology
作者单位：Guizhou University of Traditional Chinese Medicine
会议名称：《第十六届中国实验动物科学年会》
会议日期：2023年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
摘 要：Objective To explore the possible mechanism of Huang jing in the treatment of T2DM by using network *** Using TCMSP database to obtain the active components and targets of Xanthine,combined with OMIM,GeneCards,DrugBank,DisGeNET and other databases to screen T2DM-related gene targets,extracting drug-disease target intersection with R software,and constructing drug-component-disease-target network *** intersection target PPI network is constructed through the String database and Cytoscape *** GO function and KEGG pathway enrichment analysis of the target of T2DM are performed using R software and Metascape *** 12 active ingredients and 76 targets are selected from Huang *** proteins involved AKT1,VEGFA,PPARG,CASP3,FOS,MAPK14,MMP9,etc.818 items are obtained by GO functional enrichment analysis,KEGG pathway enrichment screening obtained 80 signaling pathways is mainly concerned with the signaling pathways including whereas resistance,age-rage signaling pathway in the diabetic outcome,MAPK signaling pathway,and Relaxin signaling *** The possible mechanism of action of xanthine in the treatment of T2DM is predicted by using network pharmacology *** useful components of Xanthine mainly coordinated the intervention of T2DM by coordinating inflammatory signaling pathway,insulin-related pathway and antioxidation-related signaling pathway,providing new ideas and clues for further clinical application research.