P16 deletion ameliorates damage of intestinal epithelial barrier and microbial dysbiosis in a stress-induced premature senescence model of Bmi-1 deficiency
作者单位：Department of Human AnatomyFriendship Plastic Surgery HospitalNanjing Medical University
会议名称：《中国解剖学会2021年年会》
会议日期：2021年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：To investigate whether Bmi-1 deficiency lead to intestinal epithelial barrier destruction and microbiota dysfunction and whether p16deletion could reverse the damage of intestinal epithelial barrier and microbial ***-1 and p16 doubleknockout (Bmi-1 p16) mice were *** barrier structure and function of epithelium, the species,