Collective migrations in an epithelial–cancerous cell monolayer
作者单位：Institute of Biomechanics and Medical EngineeringApplied Mechanics Laboratory Department of Engineering Mechanics Tsinghua University Institute of Physical Chemistry Polish Academy of Sciences
会议名称：《中国力学大会-2021+1》
会议日期：2022年
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
摘 要：Collective cell migration is extensively observed in embryo development and cancer *** these processes,the interactions between cells with distinct identities and fates are of importance for boundary formation and host defense against *** this paper,we explore the collective dynamics of a two-dimensional cell mixing monolayer consisting of non-tumorigenic mammary epithelial cells and breast cancer *** show that the epithelial–cancerous cell mixing system displays unique sorting *** epithelial cells aggregate to form scattered clusters,which perform random motion with simultaneous translation and rotation,strikingly distinct from the classical persistent random walk of individual migratory *** motility of cancer cells is markedly promoted by the epithelial clusters,exhibiting remarkable contact enhancement of locomotion.A discrete model based on the Johnson–Kendall–Roberts contact mechanics is proposed to identify the influence of intercellular interactions,active migration forces and cell–substrate friction forces on the collective cell *** findings could advance our understanding of many biological processes,such as cancer metastasis and tissue morphogenesis.