Lamprey Immunity Protein enables early detection and recurrence monitoring for bladder cancer through recognizing Neu5Gc-modified UMOD glycoprotein in urine
作者单位：Dalian Medical University 辽宁师范大学 大连医科大学附属第二医院 大连医科大学附属中心医院 大连大学附属中山医院
会议名称：《2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学...》
会议日期：2022年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：The clinical management of bladder cancer(BCa) is hindered by the lack of reliable *** aimed to investigate the potential of lamprey immunity protein(LIP),a lectin that specifically binds to multi-antennary sialylated N-glycolylneuraminic acid(Neu5Gc)structures on UMOD glycoproteins in the urine of BCa *** BCa patients had higher levels of LIP-bound Neu5Gc in urine,compared to that of the healthy participants and patients receiving postoperative *** addition,lectin chip assay and mass spectrometry were used to analyze the glycan chain structure,which can recognize the UMOD glycoprotein decorated with multi-antennary sialylated Neu5Gc ***,compared with urine samples from healthy patients(N= 2821,T/C= 0.12 ± 0.09) or benign patients(N= 360,T/C= 0.11 ± 0.08),the range of urine T/C ratio detected using LIP test paper was 1.97 ± 0.32 in patients with bladder cancer(N= 518) with significant difference(P 0.0001).Our results indicate that LIP may be a tool for early BCa identification,diagnosis,and ***5Gc-modified UMOD glycoproteins in urine and Neu5Gc-modified N-glycochains and sialyltransferases may function as potential markers in clinical trials.