Investigating the changes of sleep structure and cortisol responses to the Trier Social Stress Test in good sleepers with different sleep reactivity
作者单位：The first affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital) 安徽医科大学附属巢湖医院
会议名称：《中国睡眠研究会第十四届全国学术年会》
会议日期：2022年
摘 要：Study Objectives: The purpose of this study was to explore whether good sleepers with high sleep reactivity(H-SR) levels had insomnia-like vulnerability after stress, which was associated with more serious sleep structure damage and changes in cortisol ***: Fifty-six volunteers with good sleep were randomly divided into stress(n = 33) or without treatment(n =23, control group) conditions. According to the the Ford Insomnia Response to Stress Test Chinese Version(FIRST-C) score, the stressed subjects were respectively divided into high sleep reactivity(H-SR, n = 17) and low sleep reactivity(L-SR, n = 16) groups. Insomnia Severity Index scale(ISI), 17-item Hamilton Depression scale(HAMD-17) and 14-item Hamilton Anxiety scale(HAMA-14) were used to evaluate the sleep quality and affection of the subjects. A total of two nights were arranged in the experiment. For the first night, the subjects were allowed to adapt to the laboratory environment to eliminate the first-night effect. For the second night, all subjects completed polysomnography(PSG), while the stressed individuals received Trier Social Stress test(TSST) within 2 hours before PSG monitoring. The saliva samples were collected at 20 min before, 1 min, 15 min and 30 min after the start of the stress experiment. PSG parameters mainly include: total sleep time(TST), sleep efficiency(SE), sleep latency(SL), time in rapid eye movement sleep(REM), awakening time after falling asleep(WASO), time in non-REM sleep periods 1, 2 and 3(N1, N2, N3) and their percentages of total sleep time(N1%, N2%, N3%), REM percentage of total sleep time(REM%). Fast Fourier transform(FFT) was used to analyze the spectral density of EEG in different sleep ***:(1) PSG sleep parameters: Compared to the control group, the H-SR group had decreased TST, SE, N2, REM and REM%, and increased SL and WSAO, while the L-SR group only had decreased SE. Compared to the L-SR group, the H-SR group had significant severer changes