Impairments in brain perfusion,executive control network,topological characteristics,and neurocognition in adult patients with asymptomatic Moyamoya disease
作者单位：Beijing Tiantan HospitalCapital Medical University Department of NeurosurgeryPeking University International Hospital State Key Laboratory of Cognitive Neuroscience and Learning & IDG/Mc Govern Institute for Brain ResearchBeijing Normal University Department of RadiologyChinese PLA General Hospital Center of StrokeBeijing Institute for Brain Disorders
会议名称：《第十六届中国医师协会神经外科医师年会》
会议日期：2022年
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
关 键 词：Moyamoya disease brain perfusion neurocognition asymptomatic cerebral blood flow functional magnetic resonance imaging brain network
摘 要：Background:Asymptomatic Moyamoya disease(MMD) impairs hemodynamic and cognitive *** relationship between these changes,cerebral blood flow(CBF),and network connectivity remains largely *** aim of this study was to increase understanding of the relationship between CBF,functional networks,and neurocognition in adults with asymptomatic *** compared CBF and functional status in 26 patients with MMD and 20 healthy controls using arterial spin labeling and resting state functional magnetic resonance imaging *** the same time,a detailed cognitive test was performed in 15 patients with no cerebral or lumen infarction who were selected by magnetic resonance imaging-T2 FLAIR ***:Compared to the controls,the patients showed varying degrees of decline in their computational ability(simple subtraction,p=0.009;complex subtraction,p=0.006) and short-term memory(p=0.042).The asymptomatic MMD group also showed decreased CBF in the left anterior central and left inferior frontal gyri of the island flap with multiple node abnormalities in the brain network and reduced network *** was a significant association of these changes with cognitive decline in the MMD ***:In patients with asymptomatic MMD,disturbance of CBF and impaired brain network connections may be important causes of cognitive decline and appear before clinical symptoms.