丘脑底核CRH神经元调控快速眼动睡眠面对威胁的适应性反应（英文）
作者单位：中国科学院深圳先进技术研究院 CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Fundamental Research Institutions University of the Chinese Academy of Sciences The Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions
会议名称：《中国睡眠研究会第十四届全国学术年会》
会议日期：2022年
摘 要：When an animal faces a threatening situation while asleep, rapid arousal is the essential prerequisite for an adequate response. Here, we find that predator stimuli induce immediate arousal from REM sleep compared with NREM sleep. Using in vivo neural activity recording and cell-type-specific manipulations, we identify neurons in the medial subthalamic nucleus(mSTN) expressing corticotropin-releasing hormone(CRH) that mediate arousal and defensive responses to acute predator threats received through multiple sensory modalities across REMsleep and wakefulness. Weobserve involvement of the sameneurons in the normal regulation of REMsleep and the adaptive increase in REMsleep induced by sustained predator stress. Projections to the lateral globus pallidus(LGP) are the effector pathway for the threat-coping responses and REM-sleep expression. Together, our findings suggest adaptive REM-sleep responses could be protective against threats anduncover a critical component of the neural circuitry at their basis.