The associations between accelerometer measured sleep midpoint and digestive disease
作者单位：Guangdong Provincial People's Hospital Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical Sciences Li Chiu Kong Family Sleep Assessment Unit Department of Psychiatry Faculty of Medicine The Chinese University of Hong Kong Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical University
会议名称：《中国睡眠研究会第十四届全国学术年会》
会议日期：2022年
摘 要：Background: Accumulating evidence suggests that later sleep midpoint is associated with an increased risk of multiple diseases. However, little is known about the associations between sleep midpoint and incident digestive diseases. Thus, this study aimed to explore the association between accelerometer-measured sleep midpoint and incident digestive disease among the general population.Methods: These participants in this cohort study were recruited between 2013 and 2015. Follow-up occurred through May 2021. Sleep midpoint was measured by 7-day accelerometer data. The outcome was digestive disease, which was collected through hospital inpatient admissions and death registries. Cox regression model and linear-nonlinear analyses were used to investigate the associations between sleep midpoint and the risk of digestive disease.Results: Of 103 682 participants who were 43 to 79 years old and had accelerometer data, 92 614(mean age 62.36 years, 56.38% female) were eligible for inclusion. In the age-and sex-adjustment model, both earlier and later sleep midpoint were associated with a higher risk of digestive disease(all P 0.001). However, in the fully adjusted model, later sleep midpoint, but not earlier sleep midpoint, was associated with a higher risk of digestive disease(P 0.001). These findings were rather robust to comprehensive sensitivity analyses.Conclusions: Our findings suggest that later sleep midpoint may serve as a robust indicator of incident digestive disease among the general population. These findings provide a potential target for early intervention and prevention of digestive disease.