Genetic associations of objective rest-activity pattern with bipolar disorder: An Asian pedigree study
作者单位：Guangdong Provincial People's Hospital The Chinese University of Hong Kong Shenzhen Longgang Center for Chronic Disease Control Shenzhen Fuyong People's Hospital Shenzhen Nanshan Center for Chronic Disease Control The Affiliated Brain Hospital of Guangzhou Medical University
会议名称：《中国睡眠研究会第十四届全国学术年会》
会议日期：2022年
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
摘 要：Background: Alterations of rest-activity pattern are common among the patients with bipolar disorder and increasingly seen among their family members. There is emerging evidence of rest-activity pattern alterations with regard to the emergence of psychopathologies in the high-risk population. However, the genetic associations between rest-activity pattern and bipolar disorder are largely unknown. The current study aimed to determine the genetic associations of objective rest-pattern and bipolar disorder by using a large-scale pedigree ***: A total of 835 participants(58.6% female;mean age: 28.93 ± 16.53 years old) of 320 families were recruited in this study from a bipolar offspring study, of whom 120 participants had bipolar disorder. All the participants were invited to accomplish the screening clinical interviews to determine the diagnosis of bipolar disorder. One-week Actigraphy was employed to continuously measure rest-activity pattern, including rest pattern parameters, activity pattern parameters, and circadian rhythm parameters. The activity data were cleaned and analyzed carefully by the GGIR package(version 1.11-0) in R project. The Sequential Oligogenic Linkage Analysis Routines(SOLAR) program was used to analyze the genetic associations of objective rest-activity pattern with bipolar ***: Totally, 9 rest pattern parameters, 8 activity pattern parameters, and 7 circadian rhythm parameters derived from Actigraphic data were examined. Eight rest pattern parameters, 7 activity pattern parameters, and 3 circadian rhythm parameters were found to have significant heritability(h2 range: 0.22 – 0.49). Three activity pattern parameters and two circadian rhythm parameters were found to be genetically associated with bipolar disorder. After further adjustment by the Benjamini-Hochberg false discovery rate control procedure, only the genetic associations of start time of active period(ρg = 0.51, Q =.03) and daytime total sustained inactivity