Association of maternal plasma manganese with the risk of spontaneous preterm birth: A nested case-control study in China
作者单位：Beijing Obstetrics and Gynecology HospitalCapital Medical University Beijing Maternal and Child Health Hospital Beijing Luhe HospitalCapital Medical University Peking University Health Science Center
会议名称：《中国营养学会第十五届全国营养科学大会》
会议日期：2022年
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
关 键 词：manganese essential trace elements spontaneous preterm birth
摘 要：Preterm birth is one of the important causes of perinatal death. Identifying the high-risk factors of preterm birth is conducive to the formulation of clinical interventions to reduce the occurrence of preterm birth. As an essential trace element, manganese is harmful to health in excess or in deficiency. However, previous studies have inconsistent conclusions on the relationship between manganese and preterm birth. This study aimed to further clarify the relationship between manganese levels during pregnancy and spontaneous preterm birth(SPB). Methods The research is an nested case-control study and is carried out on the basis of the mother-child health cohort. The cohort population was recruited from July 2017 to November 2021. Singleton pregnant women who were registered in the Beijing Obstetrics and Gynecology Hospital, Capital Medical University in the first trimester, aged 18-45 years and had no complications were recruited. Pregnant women who met the diagnosis of SPB and had blood samples in the first and third trimesters were selected as the preterm labor group, and the full-term pregnant women were included in the control group(number of people matched 1:1). Serum manganese concentrations were determined using an inductively coupled plasma method. Logistic regression was used to analyze the relationship between serum manganese levels and SPB. Results A total of 486 pregnant women were eventually included from 50,000 pregnant women in the study(preterm group n=244, control group n=242). The average age was 31 years old, and there was no statistical difference in the gestational age of blood collection, economic level and education level between the two groups. Maternal serum manganese concentrations increased with gestational age during pregnancy(median, 0.81 ng/ml in the first trimester vs. 1.2 ng/ml in the third trimester). However, there was no significant difference in serum manganese concentration between the two groups either in first or third trimeste