Associations of shift work and sleep problems with symptomatic COVID-19 infection
作者单位：The Affiliated Brain Hospital of Guangzhou Medical University Guangdong Provincial People's Hospital
会议名称：《中国睡眠研究会第十四届全国学术年会》
会议日期：2022年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：Background: Previous evidence indicates the sleep and circadian disruption is essential in the regulation of immune function, and shift workers and individuals with sleep problems are speculated to be associated with the risk of COVID-19 infection. Therefore, we aimed to investigate the associations of shift work and sleep problems with symptomatic COVID-19 infection in a large population-based cohort. Methods: This was a population-based cohort study based on the UK biobank, and 421373 participants resident in England and recruited between 2006 and 2010 were included. Exposures including shift work and sleep problems were obtained. Main outcome was testing results of COVID-19(March 16, 2020 to May 31, 2020). Logistic regression analysis was ***: A total of 1470(0.35%) were positive for COVID-19 infection. Among paid employers or self-employers, the frequency and type of shift work [sometimes: OR = 1.95, 95% CI: 1.57-2.43, usually or always: OR = 2.34, 95% CI: 1.94-2.81;day shift: OR = 1.98, 95% CI: 1.61-2.44, night shift: OR = 2.35, 95% CI: 1.94-2.84] were associated with the risk of COVID-19 infection after adjustment for demographics, behavioral factors, as well as mental and medical comorbidity. Daytime sleepiness was weakly associated with increased risk of infection [sometimes: OR = 1.22, 95% CI: 1.08-1.38;often: OR = 1.19, 95% CI: 0.91-1.56] in final model. No associations of sleep duration, insomnia symptoms, chronotype, and snoring with COVID-19 infection were found in final model. Sensitivity analyses recruiting 6100 participants with test results for COVID-19 infection confirmed similar ***: Shift work may enhance susceptibility towards symptomatic COVID-19 infection. Besides, daytime sleepiness may also be weakly associated with symptomatic COVID infection. Therefore, preventive strategies targeting at COVID-19 infection may set priority to those shift workers.