Galectin-9/CD44 signaling-induced activation on CD11c high macrophages contribute to the compromised spiral artery remodeling in preeclampsia
作者单位：Laboratory for Reproductive ImmunologyHospital of Obstetrics and GynecologyFudan University Shanghai Medical College
会议名称：《第十四届全国免疫学学术大会》
会议日期：2021年
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
关 键 词：galectin-9/CD44 CD11chigh macrophage spiral artery remodeling autophagy ubiquitination preeclampsia
摘 要：Macrophages(Mφ) are involved in spiral artery remodeling(SAR) in normal ***,the underlying mechanism of Mcp involved in preeclampsia(PE) remains ***,we found that trophoblasts-derived galectin-9(gal-9) was highly expressed in placenta and plasma of PE patients as well as in the PE mouse ***-9 administered caused development of PE features,whereas gal-9 blockade was *** found that rhGal-9 treatment enhanced the adhesion of decidual Mcp to extravillous trophoblast(EVT) cells via activating FAK/Src ***,gal-9 induced the expansion of CD11 c Mcp and enhanced their activated phenotype via interacting with ***-1(3 and TNF-α produced by CD11 c Mcp after gal-9 stimulation remarkably increased the apoptosis of EVT cells,which is adverse to *** addition,gal-9/CD44 interaction promoted the ubiquitination of RIPK1 and induced autophagy via the AMPK-mTOR *** degradation of ubiquitinated PKR1 mediated by the autophagy manner,led to the decreased angiogenic factor IL-8 production by ***,the tube formation and SAR were impaired due to the less ***,our results revealed a new mechanism by which Mφ mediated abnormal SAR,and gal-9/CD44 is suggested to be a potential therapeutic target for PE.