Dynamic changes of key metabolites during liver fibrosis in rats by UPLC-MS
作者单位：State Key Laboratory for the Diagnosis and Treatment of Infectious DiseasesFirst Affiliated HospitalCollege of MedicineZhejiang University Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases
会议名称：《2018年浙江省检验医学学术年会》
会议日期：2018年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：Introduction:Fibrosis is the single-most important predictor of significant morbidity and mortality in patients with chronic liver *** non-invasive tests for monitoring fibrosis are lacking,and new biomarkers of liver fibrosis and function are ***:Dynamic changes in metabolic profiles and biomarker concentrations in rat serum during liver fibrosis progression were investigated using ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass ***:To investigate the dynamic changes of metabolites during the process of liver fibrosis,sera from control and fibrosis model rats were analyzed at five different time *** investigated the association of liver fibrosis with 21 metabolites including hydroxyethyl glycine,l-threonine,