Spi-B promotes the recruitment of tumor-associated macrophages via enhancing CCL4 expression in lung cancer
作者单位：Tianjin medical university
会议名称：《第十四届全国免疫学学术大会》
会议日期：2021年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：tumor-associated macrophages lung cancer CCL4 CD163 Spi-B
摘 要：Tumor immune escape plays a critical role in malignant tumor progression and leads to the failure of anticancer ***-B,a lymphocyte lineage-specific Ets transcription factor,participates in mesenchymal invasion and favors metastasis in human lung ***,the mechanism through which Spi-B regulates the tumor immune environment has not been *** this study,we demonstrated that Spi-B enhanced the infiltration of tumor-associated macrophages(TAMs) in the tumor microenvironment using subcutaneous mouse models and clinical samples of human lung ***-B overexpression increased the expression of TAM polarization-and recruitment-related genes,including ***,deleting CCL4 inhibited the ability of Spi-B promoting macrophage *** data suggest that Spi-B promotes the recruitment of TAMs to the tumor microenvironment via upregulating CCL4 expression,which contributes to the progression of lung cancer.