The novel role of endoplasmic reticulum–associated degradation in brown adipocytes
作者单位：Shanghai Institute of Nutrition and Health CAS
会议名称：《第四届中国生物物理学会代谢生物学分会学术研讨会》
会议日期：2021年
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
摘 要：正Organelles within a cell communicate with each other to exchange information and maintain cellular homeostasis. Indeed, various diseases such as neurodegeneration and type-2 diabetes are linked to dysregulation of organelle communication. However, the underlying molecular mechanism remains largely unclear. Sel1L-Hrd1 endoplasmic reticulum （ER）-associated degradation （ERAD）is a principal quality control mechanism which clears misfolded proteins in the ER for proteasomal degradation in the cytosol. Here we showed that Sel1L-Hrd1ERAD controls ER-mitochondria contacts and mitochondrial dynamics in brown adipocytes. Using transmission and 3D scanning electron microscopy,