The HDAC3 Enzyme Activity Regulates Skeletal Muscle Fuel Metabolism
作者单位：Division of EndocrinologyDiabetesand MetabolismDepartment of MedicineBaylor College of Medicine Department of PhysiologyPerelman School of MedicineUniversity of Pennsylvania Department of PediatricsJan and Dan Duncan Neurological Research InstituteBaylor College of Medicine Department of Molecular and Cellular BiologyBaylor College of Medicine
会议名称：《2018年浙江省医学会儿科学分会学术年会》
会议日期：2018年
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
摘 要：Histone deacetylase 3 (HDAC3) is a major HDAC whose enzyme activity is targeted by many small molecule HDAC inhibitors for treating a variety of conditions,but its enzyme activity is largely dispensable for its function in embryonic development and liver lipid *** AC 3 plays a pivotal role in regulating muscle insulin sensitivity and exercise *** we address whether the function of HDAC3 in skeletal muscles requires its enzyme ***3 gains its activity through binding to the Deacetylase Activation Domain (DAD) of theNuclear Receptor Co-repressors (NCORs).