Phase separation in cell polarization
作者单位：Institutes of Biomedical SciencesShanghai Medical CollegeFudan University
会议名称：《2021年全国生物相分离和相变学术研讨会》
会议日期：2021年
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
关 键 词：cell polarity liquid-liquid phase separation asymmetric division neuroblasts
摘 要：Uneven distribution and local concentration of protein complexes on specific membrane domains is a fundamental property of cell *** the asymmetric division of Drosophila neuroblasts,the conserved Par3/Par6/aPKC complex and cell fate determinants（***） are localized on the apical and basal cortex,respectively,to set up the apical-basal polarity,and then are unequally segregated into two daughter cells to achieve distinct *** have discovered that through multivalent interactions,both Par3/Par6/aPKC complex and Numb undergo liquid-liquid phase separation（LLPS） both in vitro and in vivo,Perturbation of LLPS of these proteins impair their polarized localization and lead to defects of neuronal *** further identified a new regulator of Par3, which promotes LLPS of Par3 and its recruitment of Numb at the apical junctions of mouse radial glia,thus modulating the attachment and multipotency of radial glial cells in the developing neocortex via the Par3-Numb-Notch *** propose that LLPS may be a common and conserved mechanism for the establishment of cell polarity.