High expression of PPP2R3A predicts poor outcome in hepatocellular carcinoma patients after liver transplantation
作者单位：The Third Medical Center of Chinese PLA General Hospital
会议名称：《2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛》
会议日期：2021年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Protein phosphatase 2 regulatory subunit B' ' α Hepatocellular carcinoma Liver transplantation Prognosis Alpha-fetal protein
摘 要：BACKGROUND: Protein phosphatase 2 regulatory subunit B alpha(PPP2 R3 A) gene has been reported in other tumors, but the influence of PPP2 R3 A gene expression on the occurrence, development, and prognosis of hepatocellular carcinoma(HCC) remains ***: To investigate whether the PPP2 R3 A gene could be used to predict tumor recurrence and survival of HCC patients after liver transplantation(LT).METHODS: Collected diseased liver tissues of HCC patients after LT, as well as their clinical data and follow-up information. The immunohistochemical method was used to detect the expression of PPP2 R3 A protein in the tissues of 108 patients with primary liver cancer. The c2 test was used to analyze the relationship between PPP2 R3 A protein expression levels and the clinicopathological features of tumors. The Kaplan-Meier method was used to analyze overall postoperative survival. The COX proportional hazard model was used to analyze adverse prognostic ***: Immunohistochemistry showed that the PPP2 R3 A protein was mainly expressed in the cytoplasm of HCC cells. Compared to corresponding peritumoral tissues, expression was higher in HCC tissues(P≤0.001). Correlation analysis showed that high PPP2 R3 A expression was correlated with preoperative serum alpha-fetoprotein(AFP) levels(P=0.003), TNM-t stage(P≤0.001) and envelope invasion(P=0.001). Univariate analysis showed that overall survival(P≤0.001) and recurrence-free survival(P=0.025) of patients with high PPP2 R3 A expression(≥ 4 points) were poor compared to those with low expression( 4 points). The overall survival rate or recurrence-free survival rate at 1, 2, and 3 years with high PPP2 R3 A expression were 73%, 38%, and 23%, or 31%,23%, and 23% respectively. Multivariate analysis showed that high PPP2 R3 A expression(HR = 2.900,95%CI: 1.411–5.960, P=0.004) was an independent survival risk factor of HCC patients after LT, and it was also an independent predictor of postoperative tumor recurrence. This