Cu-catalyzed Deacylation Arylation of 1H-1,2,3-Benzotriazoles
作者单位：College of Chemistry and Chemical Engineering Northwest Normal University 西北师范大学
会议名称：《中国化学会·第十五届全国有机合成化学学术研讨会》
会议日期：2018年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
关 键 词：Deacylation Arylation Diaryliodonium salts 1-H-1,2,3-Benzotriazoles Transition Metal Catalysis
摘 要：Benzotriazole can be found in some bioactive molecules as a nitrogen-containing *** of their interesting structure, high reactivity, and anticancer activity, N-substituted benzotriazoles are widely used in synthetic organic chemistry, materials science, and pharmaceuticals. In the past two decades, hypervalent, λ-iodane organic compounds have been efficiently utilized as successful reagents in organic chemistry. Diaryliodonium salts were used widely in organic synthesis because of their low toxicity, stability, high reactivity, and ***, diaryliodonium salts are particularly important among the quickly growing number of aryliodonium compounds because they afford efficient arylation of diverse nucleophiles, in particular heteroatom *** the other hand,recent applications of diaryluodonium salts have focused on metal-catalyzed arylation reaction under mild *** years, our group achieved the Pd-catalyzed C-H arylation of benzothiazoles and triazoles with diaryliodonium salts to prepare 2-arylbenzothiazoles and 5-aryltriazoles. We reported herein a cheap metal catalysed N-deacylation and thereafter N-arylation of N-acetylbenzothiazoles with diaryliodonium *** reaction was proceeded regioselectively to form N1-arylbenzotriazoles in good to excellent yield under mild conditions.