The synergic effect of Sr2+ and Mg2+ on the stabilization of amorphous calcium phosphate
作者单位：Department of ChemistryZhejiang University Qiushi Academy for Advanced StudiesZhejiang University
会议名称：《第十一届全国化学生物学学术会议》
会议日期：2019年
学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学]
关 键 词：Biominerallization Sr2+ Mg2+ ACP nucleation
摘 要：Amorphous calcium phosphate(ACP) is a meta-stable precursor phase for bone formation and it can transform into the thermodynamic stable mineral phase,hydroxyapatite(HAP,the main inorganic phase in bone),under physiological *** biological system,it has been documented that Mg can effectively stabilize ACP to ensure a regulation of biomineralization kinetics. In this study,we investigate the effect of another alkaline earth metal ion,Sr,on ACP *** the human body,99.9% Sr is located in bones,and administered Sr is almost exclusively precipitated in bone. Sr is vital to young bone tissues formation.2 The role of Sr on ACP formation and its transformation needs to be *** precipitation of ACP and the crystallization of HAP are accompanied by an abrupt drop in *** find that Sr itself have less stabilization effect on ACP in comparison with Mg pH ***,the presence of Sr can significantly enhance the stabilization of Mg on ACP due to a synergic *** chemical analysis reveals more Mg should be excluded from ACP to initiate the crystallization of HAP when Sr ions are co-existed in the amorphous *** change results in additional energy barriers for the solid phase transformation to provide a better stabilization effect on ACP,which benefit bone *** revealing of multiple ions effects on the phase transformation of amorphous minerals might shed lights on the understanding of biomineralization process as well as the fabrication of stable amorphous phase,which has wide applications in drug delivery, vaccine reservations, environment treatments, and lithium ion battery.