Peptoid nanostructures and liquid biopsy
作者单位：National Center for Nanoscience and Technology
会议名称：《第十一届全国化学生物学学术会议》
会议日期：2019年
学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学]
关 键 词：peptoid nanostructure liquid biopsy extracellular vesicle Alzheimer’s disease cancer
摘 要：Blood-based detection of biomarkers is highly needed for the early diagnosis,dynamic monitoring,and prognosis evaluation of *** focus on the developing micro-nanotechnologies for the blood-based detection of cancer and neurodegenerative *** construct antibody-mimetic self-assembling peptoid nanosheets with amyloid beta 42（Aβ42）-recognizing loops displayed on the surface,and develop a label-free sensor for the early detection of AD *** loop-displaying peptoid nanosheet is demonstrated to have high affinity to serum Aβ42,and to be able to identify mild cognitive impairment（MCI） and AD sera with high *** also develop a flow cytometry-based assay for the detection and molecular analysis of tumor-derived serum extracellular vesicles（EVs） with the aid of microbead *** microbead-assisted flow cytometry EV assay is demonstrated to be able to diagnose breast cancer,gliomas,pituitary adenoma,and non-small cell lung cancer with high sensitivity and *** results show great potential of micro-nanotechnologies in the biomedical detection,and will help to the personalized management of diseases.