Horizontal gene transfer of Fhb7 from a fungus underlies Fusarium head blight resistance in wheat

作     者：Hongwei Wang Silong Sun Wenyang Ge Lanfei Zhao Bingqian Hou Kai Wang Zhongfan Lyu Liyang Chen Shoushen Xu Jun Guo Min Li Peisen Su Xuefeng Li Guiping Wang Cunyao Bo Xiaojian Fang Wenwen Zhuang Xinxin Cheng Jianwen Wu Luhao Dong Wuying Chen Wen Li Guilian Xiao Jinxiao Zhao Yongchao Hao Ying Xu Yu Gao Wenjing Liu Yanhe Liu Huayan Yin Jiazhu Li Xiang Li Yan Zhao Xiaoqian Wang Fei Ni Xin Ma Anfei Li Steven S Xu Guihua Bai Eviatar Nevo Caixia Gao Herbert Ohm Lingrang Kong 

作者单位：State Key Laboratory of Crop Biology College of Agronomy Shandong Agricultural University 

会议名称：《第十九届中国作物学会学术年会》

会议日期：2020年

学科分类：09[农学] 0904[农学-植物保护] 090401[农学-植物病理学] 090402[农学-农业昆虫与害虫防治] 

关 键 词：Fusarium head blight (FHB) Glutathione S-transferase (GST) Thinopyrum elongatum Horizontal gene transfer(HGT) Wheat breeding for FHB resistance 

摘      要：Fusarium head blight(FHB) has devastated wheat production globally. Mycotoxin, especially trichothecenes, produced by the Fusarium pathogen is a major safety concern for human health and animal production. Fhb7 discovered from a wheat relative, Thinopyrum elongatum, shows a stable major effect on FHB resistance. Here, we cloned the Fhb7 by assembling the Triticeae E genome of T. elongatum, a wheatgrass species used in wheat distant hybridization breeding. Fhb7 encodes a glutathione S-transferase(GST) and confers broad resistance to Fusarium species by detoxifying trichothecenes via de-epoxidation. Presence of GST homologs in Epichlo? fungal species but not in plants supports that T. elongatum gained GST via horizontal gene transfer(HGT) from an endophytic Epichlo? that established symbiosis with temperate grasses. When introgressed into wheat, GST confers resistance to both FHB and crown rot in diverse wheat backgrounds without yield penalty, providing an excellent Fusarium resistant source for breeding.