A Super-enhancer Driven by FOSL1 Controls miR-21 Expression in Head and Neck Squamous Cell Carcinoma
作者单位：Department of Oral and Maxillofacial Surgery Guanghua School of StomatologyHospital of Stomatology Sun Yat-sen University Guangdong Provincial Key Laboratory of Stomatology Sun Yat-sen University Department of Medicinal Chemistry Institute for Structural Biology Drug Discovery and Development School of Pharmacy and the Massey Cancer CenterVirginia Commonwealth University Department of Oral Pathology Guanghua School of Stomatology Hospital of Stomatology Sun Yat-sen University Department of Oral and Maxillofacial Surgery Nanfang Hospital Southern Medical University Department of Oral and Craniofacial Molecular Biology Philips Institute for Oral Health Research School of Dentistry Virginia Commonwealth University
会议名称：《2020年中华口腔医学会口腔生物医学专业委员会第十次全...》
会议日期：2020年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：MiR-21 is one of the most common oncogenic miRNAs that is upregulated in many solid cancers by inhibiting its target genes at the posttranscriptional level. However, the upstream regulatory mechanisms of miR-21 are still not well documented in cancers. Here, we identify a super-enhancer associated with mi R-21 (miR-21-SE) by analyzing the mi R-21 genomic regulatory landscape in head and neck squamous cell carcinoma (HNSCC).