Cyano-Borrowing Reaction:Nickel-Catalyzed Direct Conversion of Cyanohydrins and Aldehydes/Ketones to α-Cyano Ketone
作者单位：School of Chemistry and Chemical EngineeringSouthwest University 西南大学
会议名称：《中国化学会·第十六届全国有机合成化学学术研讨会》
会议日期：2019年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
关 键 词：Cyano-Borrowing Reaction Nickel-Catalyzed β-Cyano Ketone Cyanohydrins
摘 要：A direct nickel-catalyzed,high atom-and step-economical reaction of cyanohydrins with aldehydes or ketones via an unprecedented cyano-borrowing reaction has been *** of the C-CN bond of cyanohydrins,aldol condensation followed by conjugate addition of cyanide to α,β-unsaturated ketones proceeded to deliver a range of racemic β-cyano ketones with good to high *** practical procedure with the use of commercial and lower-toxic CN source bodes well for wide application of this protocol.