A multifunctional supramolecular vesicle based on complex of cystamine dihydrochloride capped pillar[5]arene and galactose derivative for targeted drug delivery
作者单位：Analysis Center of College of Science & TechnologyHebei Agricultural University Shaanxi Key Laboratory of Natural Products & Chemical BiologyCollege of Chemistry and PharmacyNorthwest A&F University
会议名称：《中国化学会第三届全国糖化学会议》
会议日期：2019年
学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 0702[理学-物理学]
摘 要：A multifunctional supramolecular vesicle（CAAP5 G） based on the complex of CAAP5 and galactose derivative（G） assembled via host-guest interaction was *** Human embryonic kidney T（293 T） cells as experimental models,the cytotoxic effects of CAAP5 G was investigated to 0-50 μmol/L for 24 ***,the CAAP5 G vesicles revealed low-toxicity to 293 T cells,it was critical to designing drug ***,we have evaluated Doxorubicin hydrochloride（DOX）-loaded CAAP5 G vesicles anticancer efficiency,where DOX-loaded CAAP5 G vesicles and free DOX incubated with Human hepatocellular carcinoma cancer cell（HepG2 cells） and293 T cells for 24 h,48 h,72 *** turned out that CAAP5 G vesicles encapsulated anticancer drug（DOX） could decrease DOX side-effect on 293 T cells and increase DOX anticancer *** importantly,the cysteamine as an adjuvant chemotherapy drug was released from CAAP5 G vesicles in HepG2 cells where a higher GSH concentration *** adjuvant chemotherapy efficiency was evaluated,where free DOX and DOX-loaded CAAP5 G vesicles incubated with DOX-resistance HepG2 cells（HepG2-ADR cells） for 24,48,72 h,*** results revealed that DOX encapsulated by CAAP5 G vesicles could enhance the cytotoxicity of DOX and provide insights for designing advanced nano-carriers toward adjuvant chemotherapies.