Long noncoding RNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in oral squamous cell carcinoma through interaction with MCM5
作者单位：潍坊医学院附属医院 上海交通大学医学院附属第九人民医院
会议名称：《2020年全国口腔颌面-头颈肿瘤学术大会暨中华口腔医学...》
会议日期：2020年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Long noncoding RNA lnc-POP1-1 VN1R5 MCM5 Cisplatin resistance Oral squamous cell carcinoma
摘 要：Purpose/Background:Cisplatin resistance is a major therapeutic challenge in advanced oral squamous cell carcinoma(OSCC). Long noncoding RNAs(lncRNAs) play a regulatory role in cisplatin resistance in OSCC. LncRNA lnc-POP1-1 was revealed as one of the downstream genes regulated by the cisplatin resistance-related protein VN1 R5 in OSCC cells. Here, we aimed to investigate the functions and molecular mechanisms of VN1 R5 and its downstream lncRNA lnc-POP1-1 in mediating cisplatin resistance in OSCC cells.