p53-R273H Upregulates Neuraminidase-1 to Promote Cancer Cell Migration
作者单位：Center for Yunnan plateau Biological Resources Protection UtilizationCollege of Biological Resource and Food EngineeringQujing Normal University College of Chemistry and Environmental ScienceQujing Normal University
会议名称：《中国生物化学与分子生物学会2020全国学术在线会议》
会议日期：2020年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：p53-R273H NEU1 ITGB4 AKT Cell migration
摘 要：Accumulating evidence indicates that hotspot p53 mutants have gain-of-function to promote cancer cell migration and ***,the molecular mechanisms are not completely *** have previously shown that hotspot p53 mutant p53-R273 H promotes the expression of Nrp2,resulting in cancer cell mobility and ***,we show that a hotspot mutation,p53-R273 H,promotes non-small cell lung cancer(NSCLC) cell migration and upregulates the mRNA and protein expression of neuraminidase-1(NEU1),a sialidase involved in cell proliferation,cell migration and *** of NEU1 leads to upregulation of integrin beta4 which significantly inhibits NSCLC cell migration induced by p53-R273 ***,p53-R273 H promotes NEU1 transcription via activation of AKT ***,NEU1 expression is upregulated in human NSCLC samples harboring mutant p53 and is associated with poor clinical ***,this study highlights an important role of NEU1 in p53-R273 H-induced NSCLC cell migration and provides a potential target for NSCLC diagnosis and treatment.