LID-2 is an E3 ubiquitin ligase important for lysosome membrane integrity
作者单位：National Laboratory of BiomacromoleculesCAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of Sciences College of Life SciencesUniversity of Chinese Academy of Sciences
会议名称：《第五届中国秀丽线虫大会》
会议日期：2018年
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
摘 要：正Lysosomes are membrane-bound organelles containing more than 60 acid hydrolases that function in the degradation of macromolecules derived from endocytosis,phagocytosis or autophagy *** rupture of lysosomal membrane causes leakage of luminal hydrolases to the cytosol,resulting in unwanted degradation of cellular components that may lead to cell ***,