Association between polymorphisms in premiRNA genes and risk of oral squamous cell cancer in a Chinese population
作者单位：中国医科大学附属口腔医院
会议名称：《2019第一届全国口腔颌面-头颈肿瘤学术大会——聚合引领、协同发展》
会议日期：2019年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：polymorphisms premiRNA OSCC Chinesepopulation
摘 要：研究目的:This case-control study is to evaluate the roles of the polymorphisms in pre-miRNAs on risk of oral cancer in a Chinese population. 研究方法:The genotypes of three polymorphisms were determined in 340 patients with oral squamous cell cancer and 340 healthy controls. ORs and 95%CIs were calculated.研究结果:For miR-499 rs3746444, individuals carrying homozygous CC genotype had increased risks of oral cancer compared with the homozygous wild TT genotype. The C allele of miR-499 rs3746444 was associated with a higher risk of oral cancer with significant odds ratio of 1.453. The associations between miR-499 rs3746444 and miR-146 a rs2910164 polymorphisms with the susceptibility of oral squamous cell cancer were significant in males. 研究结论:This polymorphisms may contribute to genetic susceptibility to OSCC.