CircRtn4 Acts as the Sponge of miR-24-3p to Promote Neurite Growth
作者单位：Shenzhen Key Laboratory for Neuronal Structural BiologyBiomedical Research InstituteShenzhen Peking University-The Hong Kong University of Science and Technology Medical Center
会议名称：《中国生物化学与分子生物学会2020全国学术在线会议》
会议日期：2020年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：CircRtn4 MiR-24-3p Neurite Growth
摘 要：Circular RNAs(circRNAs) are covalently closed single-stranded RNA molecules derived from precursor mRNA(pre-mRNA)back-splicing and play an important role in many diseases or life *** circRNAs are usually expressed at relatively low levels,recent studies have showed that some of them are enriched in the mammalian brain,and many of their functions remain *** expressed CircRtn4 in the mouse brain has been reported that the expression increased significantly with the differentiation of *** our study,knockdown of circRtn4 inhibited neurite growth,while overexpression of circRtn4 significantly increased neurite *** performing Dual-luciferase reporter assay,we identified miR-24-3 p as the circRtn4-associated *** circRtn4,the knockdown of miR-24-3 p increased neurite length,while overexpression of miR-24-3 p significantly inhibited neurite *** conclusion,circRtn4 may promote neurite growth by acting as miR-24-3 p sponge.