Matching metals to proteins in cells: identification of protein targets and discovery of drug candidates
作者单位：香港大学 Department of ChemistryThe University of Hong Kong Department of MicrobiologyThe University of Hong Kong
会议名称：《第十一届全国化学生物学学术会议》
会议日期：2019年
学科分类：1007[医学-药学(可授医学、理学学位)] 100701[医学-药物化学] 10[医学]
摘 要：正Metal-and metallodrug-protein interactions play a crucial role for the action of *** is crucial to identify metal-protein interactions at a proteome-wide scale which are difficult due to diversity of metal-protein interactions（1,2）.We developed an integrated approach to identify metal-associated proteins using bismuth,silver and gallium as an example（3,4） as well as to quantify the metals for rapid metallome/proteome-wide profiling of metal-binding proteins.