Clinical significance of tumor marker for advanced gastric cancer with palliative chemotherapy: a retrospective study
作者单位：The Comprehensive Cancer Centre of Drum Tower HospitalMedical School of Nanjing University & Clinical Cancer Institute of Nanjing University
会议名称：《2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛》
会议日期：2017年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：advanced gastric cancer tumor markers survival metastasis therapy
摘 要：The predictive value of tumor markers has been previously reported a lot. However, the studies focused on advanced gastric cancer are few. In this paper, we focused on investigating the connection between clinical characteristics and the tumor markers of advanced gastric cancer, therapeutic effect of chemotherapy, and prognosis. A retrospective study including 146 advanced gastric cancer who had not received any previous anticancer therapy was performed. Blood samples for CEA, AFP, CA125, CA72-4, CA242 and CA19-9 were taken from patients before chemotherapy and monthly during their treatments. The tumor markers’ clinical value can be predicted through statistical analysis. An ROC value of 0.621 was yielded by CEA in predicting lymph node metastasis in gastric cancer, which was significantly higher than any of other markers. CA125 had the highest accuracy, specificity and sensitivity with peritoneal metastasis in gastric cancer patients. CEA and AFP were more frequently positive with hepatic metastases in gastric cancer patients. The response rate ofDecreasing, Stable and Increasing group based on CEA, CA19-9, CA125, CA72-4 and CA242 levels achieved the significance in statistic. Positive cases of CA125, CA242, CA19-9 and CA72-4 showed poor prognosis, and CA125 and CA242 indicated significant differences in 3 yearsurvival rates. These results indicated that different tumor markers in gastric cancer indicated different metastasis sites. CEA, CA242, CA19-9, CA125 and CA72-4 are predictive biomarkers in evaluating the effectiveness of chemotherapy. The elevated CA125, CA242, CA72-4 and CA19-9 levels at diagnosed had association with shorter overall survivals, especially CA125 and CA242.