Adenovirus Infection in Children Hospitalized With Pneumonia in Guangzhou,China
作者单位：Center for Disease Control and Prevention of Guangdong
会议名称：《新发与再发传染病研究论坛2020》
会议日期：2020年
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
关 键 词：HAdV Infection Pneumonia
摘 要：Background:HAdV infection can cause a variety of diseases. Although infections with HAdVs often are mild, life threatening respiratory disease can occur. Pneumonia is one of the more serious types of HAdV-induced respiratory disease in children. However, reports about HAdV infections in children hospitalized with pneumonia in China are limited. Objectives:The aim of this study was to determine the prevalence and genotype of HAdVs among children hospitalized with pneumonia in Guangzhou, China. Methods :Nasopharyngeal swabs(NPSs) were collected from children hospitalized with pneumonia in Guangzhou, China from January 2013 to June 2019. HAdVs were detected by real-time polymerase chain reaction assay, and the hexon gene was used for phylogenetic analysis. Epidemiological data were analyzed using SPSS16.0 software. Results : A total of 1778 children hospitalized with pneumonia were enrolled. The overall HAdV detection rate was 3.26%. And the yearly detection rate varied from around 2.5% in 2013-2017 to around 6% in 2018-2019. Children 5 years had the highest HAdV infection rate. 94.4% of HAdV sequences obtained in this study were belonged to species B. HAdV-B7 and HAdV-B3 were the common types detected. While HAdV-B7 showed continual circulation throughout the study period(2013-2019), HAdV-B3 strains were only found in year 2015-2016 and 2018-2019. Conclusions:HAdV prevalence is related to age and changed over time. HAdV-B was the most common species identified among children hospitalized with pneumonia in *** discrepancies in HAdV detection rates in different study period and changes of HAdV predominant types over time highlighted the importance of continued surveillance.