Immunohistochemical expression of p53,MGMT and Ki67 has prognostic value in glioma patients
作者单位：Shantou University Medical College Department of NeurosurgeryGuangdong General HospitalGuangdong Academy of Medical Sciences Southern Medical University
会议名称：《第十三届中国医师协会神经外科医师年会》
会议日期：2018年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Glioma Immunohistochemistry Prognostic factor
摘 要：Background:Glioma has a large variation in *** study was to explore whether the expression of p53,MGMT,Ki67,VEGF,EGFR or Bcl-2 can be prognostic factors in glioma ***:A total of 441 glioma patients ranging from January 2008 to March 2017 were analyzed for the immunohistochemical expression of p53,MGMT,Ki67,VEGF,EGFR and *** information from glioma patients was collated:age,gender,grade,extent of surgery,postoperative treatment and disease ***:Overall,265 patients died from *** analysis demonstrated that the independent factors of overall survival（OS）were extent of surgery（p0.001）,p53（p=0.013）,MGMT（p0.001）and Ki67（p0.001）,and the independent factors of both progression-free survival（PFS）and OS were age（p0.001;p0.001）,gender（p=0.009;p=0.027）and grade（p=0.009;p=0.009）.Additionally,high expression of p53 and MGMT was associated with poor OS in chemoradiotherapy group（p=0.029,p=0.009）,and high p53 expression was associated with poor OS for low and high grade patients（p=0.008,p=0.034）.Conclusions:Extent of surgery,p53,MGMT and Ki67 are useful prognostic factors of ***,gender and grade are prognostic factors of both PFS and OS.P53 and MGMT are prognostic factors of OS in chemoradiotherapy group.P53 is a valuable molecular marker of OS regardless of grade.