The prevalence of freezing of gait in Parkinson’s disease and in patients with different disease durations and severities Prevalence of FOG in PD
作者单位：Department of NeurosurgeryThe First Affiliated Hospital of Fujian Medical University Brain CenterQuanzhou Second People Hospital
会议名称：《第十四届中国医师协会神经外科医师年会》
会议日期：2019年
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
关 键 词：prevalence freezing gait Parkinson disease
摘 要：Background: The prevalence rates of freezing of gait（FOG） in Parkinson’s disease（PD） vary widely, ranging from 14.0% to 55.1%. Our aim is to calculate the overall prevalence of FOG in all PD patients with different disease durations and severities. Materials and Methods: Using Medline/PubMed/Embase, we carried out a systematic literature search for studies reporting the PD and clinically relevant FOG. Results: After primary screening, a total of 36 studies were identified and further analyzed for inclusion into the analysis, and 30 studies fulfilled the quality criteria and included in this meta-analysis. The overall prevalence of FOG in PD was 35.8%（95%CI 34.6%-36.9%）. The FOG identified by the Freezing of Gait Questionnaire item 3 may be more prevalent（46.4%, 95%CI 44.5%-48.3%） than the FOG identified by the Unified Parkinson’s Disease Rating Scale item 14（38.1%, 95%CI 35.9%-40.4%）. Disease duration and severity are both the clinical features associated with the FOG. The highest FOG prevalence rate in PD patients was seen in patients with disease durations ≥10 years, at 75.6%, followed that of PD patients with disease durations ≥ 5 years（57.6%）, and PD patients with disease durations 5 years（21.3%）. FOG presented in 16.1% of PD patients with Hoehn and Yahr staging（H＆Y） score ≤ 2.5, and in 73.3% of PD patients with H＆Y score ≥ 2.5. Conclusion: This meta-analysis confirms that the prevalence of FOG in PD is considerable, and highlights the need for accurate identification of FOG in PD.
