The allosteric conformation change of Cysteine-Rich Domains in activation process of Metabotropic Glutamate-like Receptor
作者单位：Institut de Génomique FonctionnelleDépartement de Pharmacologie Moléculaire Institute of Biophysics and BiochemistryHuazhong University of Science and Technology
会议名称：《The First International Symposium on Membrane Biology--The Tenth National Symposium on Membrane Biology》
会议日期：2009年
学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金：supported by the National Basic Research Program of China(Grant 2007CB914202 to JL) the National Natural Science Foundation of China(Grants 30530820 and 30470368 to JL) the Hi-Tech Research and Development Program of China(863 project)(Grants 2006AA02Z326 and 2007AA02Z322to JL) J-PP was supported by the Centre National de la Recherche Scientifique(CNRS)
关 键 词：CRD Activation Conformation Change Class C GPCRs
摘 要：正All of metabotropic glutamate-like receptors are constitutive dimer and share a cysteine-rich domain（CRD）which contains9high conserved cysteines,but how the CRD servers as a mediator in signal transduction from VFT to HD in vivo is still largely *** we first replaced the 9 conserved cysteines by alanine in mGluR2,