Commensal bacterial expressing BlcE84 disrupts intestinal epithelial barrier and induces inflammation
作者单位：State Key Laboratory of Pharmaceutical BiotechnologyNanjing Drum Tower HospitalMOE Key Laboratory of Model Animal for Disease StudyModel Animal Research CenterNanjing University Department of General SurgeryJinling HospitalMedical School of Nanjing University State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Drug DiscoveryChina Pharmaceutical University Laboratory of Gastrointestinal MicrobiologyJiangsu Key Laboratory of Gastrointestinal Nutrition and Animal HealthCollege of Animal Science and TechnologyNanjing Agricultural University
会议名称：《2018中国遗传学会第十次全国会员代表大会暨学术讨论会》
会议日期：2018年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：正Background: Alteration of commensal bacterial composition is associated with diarrhoea ***, few study to pin point the function of specific genes encoded by bacteria in regulating intestinal ***: By screening 3,983 E. coli mutants, we found that absence of bacterial lipocalin （blc） activated innate immunity in C. elegans. We further identified a SNP in several diarrhoeagenic E. coli strains that encode BlcE84, different from the BlcG84 in non-pathogenic bacteria. Exposure to BlcE84 bacteria caused decrease of lysophosphatidylethanolamine （LPE） in intestine, leading to gut epithelial barrier disruption and