Can quantitative contrast-enhanced ultrasonography predict cervical tumour perfusion response to neoadjuvant chemotherapy?
会议名称：《中国超声医学工程学会第十一届全国腹部超声医学学术会议》
会议日期：2016年
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100214[医学-肿瘤学] 10[医学]
关 键 词：ultrasonography contrast agent cervical cancer neoadjuvant chemotherapy
摘 要：Background Cervical cancer is the fourth most common female cancer,with about 527,600 new cases and 265,700 deaths reported worldwide in *** chemotherapy(NAC) followed by radical surgery provides survival benefits in patients with stage IB2-IIB cervical *** factors might be associated with the response to NAC,thus objective assessment the response of cervical cancer is important to facilitate tailored treatment for each patient in clinical practice Using CEUS to assess the tumor treatment,can detect the vessels with a diameter as small as 40μm with *** development of analytic software for CEUS further improve the response evaluation,which can provide the quantitative parameters through the quantification of the contrast-uptake kinetics within tumors due to that the contrast agents do not diffuse or leak out of the vascular compartment and behave as pure *** quantitative analysis of CEUS has been shown as a valuable technique to evaluate tumor angiogenesis and the response to antiangiogenic agents both in the animal and clinical *** To evaluate the feasibility of quantitative contrast-enhanced ultrasonography(CEUS) for predicting and assessing cervical tumor response to neoadjuvant chemotherapy(NACT)Methods Thirty-eight cases with stage IB2 or IIA cervical cancer were studied using CEUS before and after one cycle of *** quantitative CEUS parameters maximum intensity(IMAX),rise time(RT),time to peak(TTP),and mean transit time(MTT) were compared between cervical tumors and myometrium(reference zone) using Sonoliver *** and relative changes in quantitative CEUS parameters were also compared among complete response,partial response,and non-responsive *** between pre-treatment IMAX and changes in quantitative parameters were assessed after one cycle of *** There were significant changes in cervical tumor IMAX(P 0.001),RT(P 0.05),and TTP(P 0.05) after one cycle of NAC