Endothelial glycocalyx mediated vascular remodeling induced by hemodynamic environmental alteration
作者单位：Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science & Medical EngineeringBeihang University Beijing Advanced Innovation Centre for Biomedical EngineeringBeihang University National Research Center for Rehabilitation Technical Aids
会议名称：《第十二届全国生物力学学术会议暨第十四届全国生物流变学学...》
会议日期：2018年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
基 金：Grant-in Aid from the National Natural Science Foundation of China:31500763,11772036,11572028,11421202 National Key Research and Development Program in China:2017YFB0702501 the Fundamental Research Funds for the Central Universities
摘 要：Objective Vascular remodeling induced by hemodynamic stimuli contributes to the physiological processes such as wound healing and pathophysiology such as atherosclerosis, hypertension, and postspaceflight orthostatic intolerance. The importance of the endothelial glycocalyx in mechanotransduction of flow induced shear stress has been investigated over the last decade by using cultured endothelial cells. However, its role in hemodynamic stimulated vascular remodeling has triggered little attention. In the present study, we focused on the