The effect of apelin/APJ system on pathological and physiology function of vascular smooth muscle cell
作者单位：Institute of Pharmacy and PharmacologyHunan Province Cooperative innovation Center for Molecular Target New Drugs StudyUniversity of South China
会议名称：《2016年中国药学大会暨第十六届中国药师周》
会议日期：2016年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
关 键 词：Apelin VSMC Proliferation and anti-apoptotic Migration Contraction and relaxation Calcification Cardiovascular diseases Hypertension Atherosclerosis
摘 要：Apelin is endogenous ligand of APJ which is an orphan G protein-coupled receptor. Apelin/APJ has a variety of biological effects about cells. Apelin treatment can increase endothelial cell proliferation and inhibits thrombin and collagen but not ADP and TXA2-induced platelet aggregation in vitro. As for vascular smooth muscle cell（VSMC）, an integral part of the vascular wall, takes part in normal physiological processes. VSMC dysfunction is linked to the progression of various cardiovascular diseases such as atherosclerosis and hypertension. This review offers a molecular insight into the effect of apelin in regulation of proliferation and anti-apoptotic, migration, contraction and relaxation, calcification of VSMC. What is more, apelin is a promising target for managing VSMC-related disease. This review demonstrates that apelin/APJ system plays a very important role in regulating VSMCs. Proliferation: Our Laboratory first time founds that apelin enhances VSMC proliferation by PI3 K/Akt signaling transduction pathway and the regulation of cyclin D1. Anti-apoptotic: PI3 K/Akt signaling transduction pathway is a key role in treatment strategies of tumors, which involves the regulation of cellular functions, including proliferation, differentiation, apoptosis, migration and glucose transport. Further research shows that apelin suppresses serum deprivation-induced human VSMCs apoptosis. Migration: Through PI3 K/Akt signaling transduction pathway, apelin also protects VSMC from apoptosis and promote VSMC migration. The proliferation and migration of VSMCs may have effect on atherosclerosis and apelin may hopefully lead to treatment of cardiovascular diseases. Contraction and relaxation: Hypertension is a kind of cardiovascular diseases which is characterized by arterial hypertension. The emergence of apelin as an important regulator in vasodilatation has attracted increasing attention on the molecular mechanisms of nitric oxide-dependent pathways. But on the contrary, ap