The association between breastfeeding and early childhood caries in children:an update meta-analysis
作者单位：郑州大学公共卫生学院营养与食品卫生教研室 Department of Nutrition and Food HygieneCollege of Public HealthZhengzhou University Department of Healththe Third Affiliated HospitalZhengzhou University
会议名称：《达能营养中心第十八届学术年会》
会议日期：2015年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1003[医学-口腔医学] 100302[医学-口腔临床医学] 100403[医学-营养与食品卫生学] 10[医学]
摘 要：Background:Epidemiologic studies have yielded inconsistent findings between breastfeeding and risk of early childhood caries(ECC).Objective:We performed a meta-analysis to summarize available evidence from cohort,case-control,and crosssectional studies of the association between feeding pattern and breastfeeding duration and ECC risk from published observational studies.Design:Studies were identified by searching PubMed,Embase,ISI Web of Science,and the Cochrane Library from 1990 to 2015 August and by reviewing the reference lists of pertinent articles.Random-effects models were used to estimate pooled odds ratios(ORs) using ST ATA 12.0.Results:34 studies(9 birth cohorts studies,4 case-control studies and 21 cross-sectional studies) consisting of64315 children were included.Pooled results from 21 studies found no significant association for ever breastfeeding and ECC compared with never breastfeeding(OR:0.80;95%CI:0.62-1.02,P=0.069) with high evidence of heterogeneity(I= 85.8%,P 0.001).However,subgroup analysis only found ever breastfeeding could decrease the risk of ECC in the studies of 3-6 years old children(OR = 0.74,95%CI:0.57-0.98,P = 0.034),NOS ≥6(OR=0.66,95%CI:0.44-0.99,P=0.043),sample size more than 500 subjects(OR = 0.67,95%CI:0.47-0.94,P =0.021),published after 2010(OR = 0.47,95%CI:0.25-0.86,P = 0.015).Pooled analysis from 15 studies shown that breastfeeding longer than 12 months could increase the risk of ECC compared with breastfeeding shorter than12 months(OR=1.91,95%CI:1.41-2.59,P 0.001) with high evidence of heterogeneity(I=89.9%,P 0.001).Conclusions:Results of this meta-analysis suggest that ever breastfeeding may protect against ECC,and breastfeeding duration longer than 12 months is associated with higher risks of ECC.Additional research is needed to estimate the effect after adjusting for other possible confounding factors.