Tumor-penetrating peptide-based graphene oxide nanovehicles for chemo-photothermal therapy of metastatic breast cancer
作者单位：State Key Laboratory of Natural Medicines Department of Pharmaceutics China Pharmaceutical University
会议名称：《2018年第十二届中国药物制剂大会》
会议日期：2018年
学科分类：1006[医学-中西医结合] 10[医学] 100602[医学-中西医结合临床]
摘 要：正The synergistic combination of chemotherapy and photothermal therapy demonstrates excellent potential for effective treatment of metastatic breast cancer,but their efficacy is largely limited by poor delivery and penetration into tumor.Herein,we devised a tumor-penetrating peptide（iRGD）-based,PEG and hyaluronic acid（HA）dual-functionalized graphene oxide（GO）nanovehicle loaded with doxorubicin（DOX）,