Analysis of the expression and function of OX40 from patients with systemic lupus erythematosus
作者单位：2nd Hospital of Tianjin Medical University
会议名称：《第十三届全国免疫学学术大会》
会议日期：2018年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
关 键 词：Systemic lupus erythematosus OX40 CD38 Cytokine
摘 要：Background/Aims: Costimulation molecules have a central role in driving T cell activation in *** study aimed to investigate the T cell activation and the expression of OX40 and OX40L mRNA of patients with SLE and to investigate their role in ***: Forty treatment-na?ve SLE patients were ***38CD3 cells were quantitatively detected by flow *** expressions of OX40 and OX40L mRNA were measured by real-time *** effect of OX40 Ig on anti-CD3 mAb stimulated PBMCs from active SLE patients was also ***: The results showed that CD38CD3 cell was significantly increased in SLE patients and active SLE patients compared with that in healthy *** with active disease showed higher OX40 and OX40L mRNA compared with those with stable disease as well as healthy *** levels of OX40 mRNA positively correlated with *** vitro, OX40Ig significantly inhibited the IFN-γ, IL-4 and IL-17 secretion in culture ***: OX40 may provide a novel research target for the pathogenesis and therapy of SLE.